Drug Dev Ind Pharm. Feb;25(2) Evaluation of Eudragit RS-PO and Ethocel matrices for the controlled release of lobenzarit disodium. PubChem CID: Chemical Names: Eudragit RS; ; Ethyl prop- 2-enoate; methyl 2-methylpropenoate;. Although Eudragit RSPO has been widely used as sustained release material; to our knowledge the property of its combination with GC and Gd has not been.

Author: Zurisar Zologul
Country: Haiti
Language: English (Spanish)
Genre: Art
Published (Last): 18 May 2010
Pages: 33
PDF File Size: 3.47 Mb
ePub File Size: 4.43 Mb
ISBN: 435-3-41680-817-7
Downloads: 47591
Price: Free* [*Free Regsitration Required]
Uploader: Golmaran

Compression was carried out using 14 mm flat faced circular punches into tablets on an eight station eudragit rspo press tablet compression machine Rimek Minipress I Ahmadabad, India at a constant compression force. Eudragjt of Pharmaceutical Technology, Smt. Metformin hydrochloride has relatively short plasma half-life, low absolute bioavailability. Figure 6 in vitro cumulative release of metformin.

Click here to view all the property values for this datasheet as they were originally entered into MatWeb. The fit to the Higuchi model indicates that the drug release mechanism from these matrices was controlled by the diffusion step. The wide applications eudragit rspo GC and GD propose their strong hydrophobic eudragit rspo, substantial binding property, compatibility with the physiologic environment [ 17 ] and their sustaining property [ 18 eudragit rspo.

Infrared spectrum was taken by scanning the samples of pure drug and the polymers individually over a wave number range of to cm —1 using Fourier transform infrared spectrophotometer FT-IR, Shimadzu S, Shimadzu, Japan. Umekar Department of Pharmaceutical Eudragi, Smt. All the tablets of different formulations showed acceptable results with eudrgit to weight variation, fudragit content uniformity, friability.

TOP Related  60APU02 PDF

Time-controlled release – Evonik Industries AG

The eudragit rspo test was performed in triplicate. Many researchers investigated various natural, semi-synthetic and synthetic polymeric materials. To see MatWeb’s complete data sheet for this material including material property data, metal compositions, material suppliers, etcplease click eudragit rspo button below. The prepared matrix tablets were evaluated for hardness, weight variation, thickness, friability and drug content [ 19 ].

Figure 4 in vitro cumulative release of metformin. Supplemental Content Full text links. Eudragit rspo release from GC and GD matrix followed zero order and Higuchi square root kinetics respectively. Diffusion coupled with erosion might eudragit rspo the mechanism for eudragit rspo drug release from hydrophilic and hydrophobic polymer based matrix tablets which can be expected to reduce the frequency of administration and decrease the dose-dependent side effects associated with repeated administration of conventional metformin HCl Tablets.

As indicated in fig.

Evonik EUDRAGIT® RS PO Copolymer

College of Pharmacy, Kamptee, Nagpur, India for providing necessary facilities to carry out this work. Poly ethyl acrylate-co-methyl methacrylate-co-trimethylammonioethyl methacrylate chloride 1: This finding can be attributed to the hydrophobic nature of GC and GD, which retarded drug release from eudragit rspo matrix.

Table 3 gives the physical parameters such as hardness, thickness, friability and weight uniformity of eudragit rspo the fabricated tablets. The dried granules were sized by a mesh sieve and after lubrication with magnesium stearate. Property Data Eudragit rspo page displays only the text of eudraigt material data sheet.


In each formulation, the amount of the eudragit rspo ingredient is mg and the total weight of a tablet is mg. To confirm the diffusion mechanism, the data were fitted into Korsmeyer-Peppas equation [ 23 ].

We advise that you only use the original value or one of its raw conversions in your calculations to minimize rounding eudragit rspo. The ingredients were passed through a mesh sieve. The in vitro drug release profiles of the matrices are evaluated, eudragit rspo its release mechanism was studied.

Time-controlled Drug release

The composition of various formulations of the tablets with their codes is listed in Table 1. Sustained release formulation that would maintain plasma level rspp h might be sufficient for daily dosing of metformin. Figure 3 in vitro cumulative release of metformin. The eudragit rspo media used were ml of 0. Methacrylic resins Eudragit eudragit rspo particularly attractive due to their high chemical stability and compactility properties, and many literatures substantiate use in the development of control release matrix tablet eudragit rspo 1213 ].